Van de Merwe T J, Silverstone T, Ankier S I
Curr Med Res Opin. 1984;9(5):339-52. doi: 10.1185/03007998409109602.
Fourteen out-patients with major depressive disorder completed a double-blind, randomized, parallel group study using trazodone (n = 6), amitriptyline (n = 5) and matching placebo (n = 3). The average daily doses used were 223 mg and 95.3 mg for trazodone and amitriptyline, respectively, over the 28-day treatment period. Cardiovascular function was monitored with high speed ECG and by determining systolic time intervals. No significant effects of either drug on supine or standing blood pressure were demonstrated. Trazodone increased QTc on Day 1 only, and reduced heart rate and increased the PR interval on Day 15; these effects had disappeared by Day 29. Amitriptyline markedly increased heart rate, PR interval and QTc, and reduced T wave amplitude on Days 15 and 29. Trazodone had no consistent effect on systolic time intervals except to increase the LVET index, whereas amitriptyline increased both PEP index and PEP/LVET ratio on Days 15 and 29. It is concluded that amitriptyline had a much more marked effect on cardiac function than did trazodone.
14名重度抑郁症门诊患者完成了一项双盲、随机、平行组研究，使用曲唑酮（n = 6）、阿米替林（n = 5）和匹配的安慰剂（n = 3）。在28天的治疗期内，曲唑酮和阿米替林的平均日剂量分别为223毫克和95.3毫克。通过高速心电图和测定收缩期时间间期来监测心血管功能。两种药物对仰卧位或站立位血压均未显示出显著影响。曲唑酮仅在第1天增加QTc，并在第15天降低心率和增加PR间期；这些影响在第29天时已消失。阿米替林在第15天和第29天显著增加心率、PR间期和QTc，并降低T波振幅。曲唑酮对收缩期时间间期没有一致的影响，只是增加了左室射血时间指数，而阿米替林在第15天和第29天增加了射血前期指数和射血前期/左室射血时间比值。结论是，阿米替林对心脏功能的影响比曲唑酮更为显著。
