Hayes R L, Gerner R H, Fairbanks L, Moran M, Waltuch L
J Clin Psychiatry. 1983 May;44(5):180-3.
ECG effects were evaluated in 60 depressed geriatric patients in a drug-free baseline state and weekly during treatment with trazodone, placebo, or imipramine. Eighteen patients underwent crossover from placebo or imipramine to trazodone. Imipramine increased heart rate and was associated with more isolated ECG complications. Trazodone and placebo did not increase heart rate and had no other significant ECG effects.
在60名处于无药基线状态的老年抑郁症患者中评估了心电图效应，并且在使用曲唑酮、安慰剂或丙咪嗪治疗期间每周进行评估。18名患者从安慰剂或丙咪嗪交叉换用曲唑酮。丙咪嗪会增加心率，并伴有更多孤立的心电图并发症。曲唑酮和安慰剂不会增加心率，且没有其他显著的心电图效应。
