Trulson M E, Henderson L J
Eur J Pharmacol. 1984 Oct 30;106(1):195-7. doi: 10.1016/0014-2999(84)90696-4.
Buspirone, a non-benzodiazepine anxiolytic agent, produced dose-dependent increases in the activity of norepinephrine-containing locus coeruleus neurons recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on locus coeruleus neurons. These data suggest that noradrenergic neurons may not be as important in mediating anxiety states as previously suggested.
丁螺环酮是一种非苯二氮䓬类抗焦虑药，在体外从小鼠脑片中记录到，它可使含去甲肾上腺素的蓝斑神经元的活性呈剂量依赖性增加。在低钙/高镁孵育培养基中该反应未发生变化，这表明观察到的效应是丁螺环酮对蓝斑神经元直接作用的结果。这些数据表明，去甲肾上腺素能神经元在介导焦虑状态方面可能不像之前认为的那么重要。
