Cappello B, Silipo C, Vittoria A, Pratesi P
Farmaco Sci. 1984 Dec;39(12):991-1007.
Quantitative structure-activity relationships (QSAR) have been formulated for the interactions of a set of antimuscarinic agents. The antagonistic activity is found to be dependent on hydrophobic-lipophilic character and steric requirements of substituents R1 and R2 in structures of type R1R2N--CH2--CH2--+NR3R4R5. Moreover, it is shown that the incumbrance of R3, R4 and R5 groups and their polar effects on the onium ending greatly affect the antagonistic activity. A binding model which suggests new avenues for exploration is presented.
已针对一组抗毒蕈碱药物的相互作用建立了定量构效关系（QSAR）。发现拮抗活性取决于R1R2N--CH2--CH2--+NR3R4R5型结构中取代基R1和R2的疏水亲脂特性和空间要求。此外，研究表明，R3、R4和R5基团的阻碍及其对鎓端的极性作用对拮抗活性有很大影响。提出了一个为探索提供新途径的结合模型。
