使用正常人免疫球蛋白时猫的降压作用与儿童反应之间的关系。
Relation between hypotensive effect in cats and reactions in children using normal human immunoglobulin.
作者信息
Guencheva G, Manolova L, Michailova S
出版信息
Dev Biol Stand. 1977;34:159-64.
The paper deals with the rare adverse reactions following administration of normal human immunoglobulins in Bulgaria. Experimental work has shown that such lots cause hypotensive effect in cats and lead to the release of pharmacologically active substances, measured biologically and spectrofluorometrically. The same immunoglobulins give two peaks of IgG aggregates by gel-chromatography and possess high anti-complementary activity. The possible relation between hypotensive effect in cats and reactions in children is discussed.
该论文探讨了在保加利亚使用正常人免疫球蛋白后出现的罕见不良反应。实验研究表明，此类制剂可使猫产生降压作用，并导致药理活性物质的释放，通过生物学和荧光分光光度法进行测定。同样的免疫球蛋白经凝胶色谱法可得到两个IgG聚集体峰，且具有较高的抗补体活性。文中还讨论了猫的降压作用与儿童不良反应之间可能存在的关系。
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