Dumont L, Magrassi P, Parent R, Stanley P, Chartrand C
J Auton Pharmacol. 1984 Dec;4(4):251-6. doi: 10.1111/j.1474-8673.1984.tb00102.x.
The additive effects of propranolol and exercise on peripheral blood flow distribution were studied in conscious dogs. During treadmill exercise (8-10 km/h and 0% grade for 15 min.) cardiac performance increased significantly in parallel with myocardial and muscular blood flow (greater than 100%). Blood perfusion to liver and spleen decreased significantly (30% and 34%) while blood flow to other organs was unaltered. Under resting conditions propranolol only modified blood flow to liver and spleen (-50% and -38%). During exercise after propranolol a limited augmentation in cardiac performance and in myocardial and muscular blood flow was observed; splanchnic blood flow which was most affected by propranolol at rest did not further decrease during exercise after propranolol. The present observations demonstrate that propranolol, despite minor haemodynamic modifications, induces significant alterations in blood flow to splanchnic organs. The influence of beta-adrenoreceptor blockade was even more evident under conditions of augmented sympathetic activity as reflected by a significant limitation of increase in cardiac performance, myocardial and muscular blood flow and by a sustained redistribution of splanchnic blood flow during exercise after propranolol.
在清醒犬中研究了普萘洛尔和运动对外周血流分布的相加作用。在跑步机运动期间（8 - 10 km/h，0%坡度，持续15分钟），心脏功能显著增强，同时心肌和肌肉血流也显著增加（超过100%）。肝脏和脾脏的血液灌注显著减少（分别为30%和34%），而其他器官的血流未改变。在静息状态下，普萘洛尔仅改变肝脏和脾脏的血流（分别减少50%和38%）。在普萘洛尔给药后的运动期间，观察到心脏功能以及心肌和肌肉血流有有限的增加；在静息时受普萘洛尔影响最大的内脏血流在普萘洛尔给药后的运动期间并未进一步减少。目前的观察结果表明，普萘洛尔尽管对血流动力学有轻微改变，但会引起内脏器官血流的显著变化。β - 肾上腺素能受体阻断的影响在交感神经活动增强的情况下更为明显，表现为心脏功能、心肌和肌肉血流增加受到显著限制，以及在普萘洛尔给药后的运动期间内脏血流持续重新分布。
