Nambu M, Iijima T
Department of Internal Medicine, Urayasu Hospital of Juntendo University School of Medicine, Japan.
Gastroenterol Jpn. 1990 Apr;25(2):212-7. doi: 10.1007/BF02776818.
The indocyanine green (ICG) test (serum disappearance rate: K and 15 min. retention rate: R15) was performed in 15 patients with chronic hepatitis (CH) and 22 patients with liver cirrhosis (LC) before and after exercise (Master's two step method for three min.). In LC, ICG K was 0.063 +/- 0.026 (mean +/- SD) before exercise and 0.083 +/- 0.028 after exercise. ICG R15 was 31.6 +/- 15.6% and 23.3 +/- 15.3%, respectively. In CH, ICG R15 before exercise was 8.2 +/- 4.0%, as compared with that (5.7 +/- 3.6%) after exercise. Namely, the ICG test significantly (P less than 0.05) improved after exercise in chronic liver diseases. Excretion of ICG into bile after exercise increased both in gallstone patients without abnormal liver function and LC, and it markedly increased in patients with decompensated LC. There was no significant difference in ICG excreted into urine before and after exercise. These results suggest that hepatic blood flow increases through moderate exercise in chronic liver diseases.
对15例慢性肝炎（CH）患者和22例肝硬化（LC）患者在运动前和运动后（采用Master两步法，运动三分钟）进行了吲哚菁绿（ICG）试验（血清消失率：K和15分钟潴留率：R15）。在肝硬化患者中，运动前ICG K为0.063±0.026（均值±标准差），运动后为0.083±0.028。ICG R15分别为31.6±15.6%和23.3±15.3%。在慢性肝炎患者中，运动前ICG R15为8.2±4.0%，运动后为（5.7±3.6%）。也就是说，慢性肝病患者运动后ICG试验有显著改善（P<0.05）。运动后，肝功能正常的胆结石患者和肝硬化患者胆汁中ICG的排泄均增加，失代偿期肝硬化患者增加更为明显。运动前后尿中ICG排泄无显著差异。这些结果表明，慢性肝病患者通过适度运动可增加肝血流量。
