Screening for new microbial products by high-performance liquid chromatography using a photodiode array detector.

The screening for new microbial metabolites in culture filtrates from Streptomyces tendae TU 901 by high-performance liquid chromatography using a photodiode array detector resulted in detection of new compounds related to the parent compounds. Six peaks in the elution profiles of different strains could be identified as potential new nikkomycins, a group of nucleoside-peptide antibiotics. Structure elucidation confirmed the assumption for new nikkomycin structures.