Decker H, Bormann C, Fiedler H P, Zähner H, Heitsch H, König W A
Department of Microbiology, University of Tübingen, FRG.
J Antibiot (Tokyo). 1989 Feb;42(2):230-5. doi: 10.7164/antibiotics.42.230.
Two new nikkomycins were isolated from the culture broth of Streptomyces tendae Tü 901/PF 53+-3. The new compounds are the dipeptide nikkomycin pseudo-Z (psi Z) and tripeptide nikkomycin pseudo-J (psi J), which are analogues to nikkomycins Z and J. Nikkomycins pseudo-Z and pseudo-J have a C-glycosidic linkage between uracil and 5-amino-5-deoxy-D-allo-furanuronic acid, which is comparable to the C-glycosidic bond in pseudouridine. The new Cc-nucleoside nikkomycins exhibit a lower biological activity than the CN-nucleoside nikkomycins.
从天蓝色链霉菌Tü 901/PF 53+-3的培养液中分离出两种新的多氧霉素。新化合物为二肽多氧霉素假Z（psi Z）和三肽多氧霉素假J（psi J），它们是多氧霉素Z和J的类似物。多氧霉素假Z和假J在尿嘧啶与5-氨基-5-脱氧-D-阿洛呋喃糖酸之间存在C-糖苷键，这与假尿苷中的C-糖苷键相当。新的Cc-核苷多氧霉素的生物活性低于CN-核苷多氧霉素。
