甘油涡虫神经毒素与胆碱能神经末梢的结合引发了钙离子依赖的乙酰胆碱释放。
Binding of a Glycera convoluta neurotoxin to cholinergic nerve terminals triggers a Ca-dependent acetylcholine release.
作者信息
Thieffry M, Morel N, Manaranche R
出版信息
J Physiol (Paris). 1984;79(4):269-74.
PMID:6530669
Abstract
The venom glands of the annelid Glycera convoluta contain a neurotoxin which triggers ACh release from frog motor terminals and Torpedo synaptosomes. This neurotoxin binds to presynaptic, but not postsynaptic plasma membranes prepared from Torpedo electric organ. The binding site is an ectocellularly oriented protein. The binding does not require Ca. It is inhibited by pretreatment of the membrane by Concanavalin A. The toxin induced ACh release is Ca-dependent and inhibited by D 600.
摘要
环节动物旋毛甘油虫的毒腺含有一种神经毒素，它能触发青蛙运动终板和电鳐突触体释放乙酰胆碱。这种神经毒素与从电鳐电器官制备的突触前质膜结合，但不与突触后质膜结合。结合位点是一种面向细胞外的蛋白质。这种结合不需要钙离子。用伴刀豆球蛋白A预处理膜可抑制这种结合。毒素诱导的乙酰胆碱释放依赖钙离子，并被D 600抑制。
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