Nomura M, Miyagi Y, Tachi K, Sakabe Y, Sakai Y, Hishida H, Mizuno Y, Sasaki F, Koga S
Jpn Heart J. 1984 Nov;25(6):979-92. doi: 10.1536/ihj.25.979.
The computed tomography (CT) number within the region of interest (ROI) was used as a parameter to assess lung density in patients with congestive heart failure. Thirty-eight patients with valvular heart disease (VHD) and 34 patients with ischemic heart disease (IHD) were studied. Based on the New York Heart Association (NYHA) classification, 24 VHD patients were in class I or II (VHD I-II) and the other 14 were in NYHA class III or IV (VHD III-IV). Eighteen patients with IHD were in NYHA class I or II (IHD I-II) and 16 were in class III or IV (IHD III-IV). The CT number was measured bilaterally at the upper, middle and lower levels of the chest and compared with the corresponding values in 21 normal subjects (Group N). In a preliminary study on Group N, the CT numbers were insensitive to the size of the ROI, but were closely related to its location. In clinical applications, the mean values of the CT numbers in all six lung fields increased in the order of IHD I-II, to VHD I-II, IHD III-IV and VHD III-IV. Except for patients in IHD I-II, they were significantly larger than in Group N. The relationship between the CT number and the systolic and mean pulmonary arterial pressures and the pulmonary capillary wedge pressure were evaluated in 36 patients. Significant correlations were obtained in all six lung fields (r = 0.65-0.78, p less than 0.001). The results suggest that measurement of lung density by CT is useful for the quantitative evaluation of the severity of disease in patients with congestive heart failure.
将感兴趣区域（ROI）内的计算机断层扫描（CT）数值作为评估充血性心力衰竭患者肺密度的参数。对38例瓣膜性心脏病（VHD）患者和34例缺血性心脏病（IHD）患者进行了研究。根据纽约心脏协会（NYHA）分级，24例VHD患者为I级或II级（VHD I-II），另外14例为NYHA III级或IV级（VHD III-IV）。18例IHD患者为NYHA I级或II级（IHD I-II），16例为III级或IV级（IHD III-IV）。在胸部上、中、下水平双侧测量CT数值，并与21名正常受试者（N组）的相应数值进行比较。在对N组的初步研究中，CT数值对ROI大小不敏感，但与其位置密切相关。在临床应用中，所有六个肺野CT数值的平均值按IHD I-II、VHD I-II、IHD III-IV和VHD III-IV的顺序升高。除IHD I-II患者外，它们均显著高于N组。对36例患者评估了CT数值与收缩期和平均肺动脉压以及肺毛细血管楔压之间的关系。在所有六个肺野均获得了显著相关性（r = 0.65 - 0.78，p < 0.001）。结果表明，通过CT测量肺密度有助于定量评估充血性心力衰竭患者的疾病严重程度。
