Mertz D P, Eichhorn R
Klin Wochenschr. 1984 Dec 17;62(24):1170-2. doi: 10.1007/BF01712184.
Twenty male hyperuricaemic patients with normal kidney function were studied and it was found that the serum concentrations and excretions rates in the 24-hour urine of allopurinol and oxipurinol do not differ significantly after 9 days of oral treatment with either 300 mg allopurinol or a combination of 300 mg allopurinol and 60 mg benzbromarone daily. The sum of the excretion rates of the two pyrazolopyrimidines in the 24-hour urine represents 80.9% and 77.1%, respectively of the daily dose of allopurinol given alone or in combination with benzbromarone. As expected, the hypouricaemic effect of the combined therapy turned out to be stronger than that observed after monotherapy with allopurinol, due to the uricosuric component of benzbromarone. The difference was found to be highly significant.
对20名肾功能正常的男性高尿酸血症患者进行了研究，结果发现，每日口服300毫克别嘌醇或300毫克别嘌醇与60毫克苯溴马隆联合用药9天后，别嘌醇和氧嘌呤醇的血清浓度及24小时尿排泄率无显著差异。两种吡唑并嘧啶在24小时尿中的排泄率之和分别占单独使用别嘌醇或与苯溴马隆联合使用时别嘌醇日剂量的80.9%和77.1%。正如预期的那样，由于苯溴马隆的促尿酸排泄成分，联合治疗的降尿酸效果比单独使用别嘌醇治疗后观察到的效果更强。发现差异具有高度显著性。
