Arntz H R, Dreykluft H R, Leonhardt H
Fortschr Med. 1979 Jul 19;97(27):1212-4.
The serum uric acid lowering effects of 100 mg Allopurinol (A), 20 mg Benzbromarone (B) and the combination of both were tested in a randomized block-trial in 12 male patients suffering from hyperuricemia and hyperlipoproteinemia type IIb/IV. Therapy periods lasted 4 weeks each. Allopurinol lowered the uric acid concentrations from 7,54 mg/100 ml to 5,95 mg/100 ml, Benzbromarone from 7,54 mg/100 ml to 6,11 mg/100 ml and the combination from 7,54 mg/100 ml to 4,90 mg/100 ml, all three significantly. The difference between the effect of the combination drug and Allopurinol and Benzbromarone respectively was also significant. An additive effect of both components is evident. Serum creatinin concentration remained constant. Uric acid and creatinin excretion could not be evaluated because of failure of patient compliance in the collecting of urine.
在一项随机区组试验中，对12名患有高尿酸血症和IIb/IV型高脂蛋白血症的男性患者测试了100毫克别嘌醇（A）、20毫克苯溴马隆（B）以及两者联合使用降低血清尿酸的效果。每个治疗期持续4周。别嘌醇使尿酸浓度从7.54毫克/100毫升降至5.95毫克/100毫升，苯溴马隆使其从7.54毫克/100毫升降至6.11毫克/100毫升，两者联合使用则使其从7.54毫克/100毫升降至4.90毫克/100毫升，三者的效果均具有显著性。联合用药与别嘌醇和苯溴马隆的效果之间的差异也具有显著性。两种成分的相加作用明显。血清肌酐浓度保持不变。由于患者在尿液收集方面依从性差，无法评估尿酸和肌酐排泄情况。
