辅酶Q10抗代谢物对两种人类肿瘤细胞系的抑制作用。
Inhibition of two human tumor cell lines by antimetabolites of coenzyme Q10.
作者信息
Folkers K, Porter T H, Bertino J R, Moroson B
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Mar;19(3):485-90.
5-Chloro-2,3-dimethyoxy-6-octylmercapto-1,4-benzoquinone (NSC 252188) and 2,3-dimethoxy-5-hydroxy-6-phytyl-1,4-benzoquinone (NSC 277818) inhibited the human cell lines 4265 and K 562c, and the experimental animal tumor line W256; they also showed antitumor activity against Walker carcinosarcoma 256 in rats with cures; they also inhibited the mitochondrial coenzyme Q10-enzymes, succinoxidase and NADH-oxidase. 5-Chloro-2,3-dimethoxy-6-n-dodecylmercapto-1,4-benzoquinone (NSC 220334) and 5-chloro-6-omega-cyclohexylhexylmercapto-2,3-dimethoxy-1,4-benzoquinone (NSC 238136) were also active against the K 562c cell line and showed cures against the Walker carcinosarcoma 256 in rats.
5-氯-2,3-二甲氧基-6-辛基巯基-1,4-苯醌（NSC 252188）和2,3-二甲氧基-5-羟基-6-植基-1,4-苯醌（NSC 277818）抑制人细胞系4265和K 562c以及实验动物肿瘤系W256；它们对大鼠的沃克癌肉瘤256也显示出抗肿瘤活性并可治愈；它们还抑制线粒体辅酶Q10-酶、琥珀酸氧化酶和NADH氧化酶。5-氯-2,3-二甲氧基-6-正十二烷基巯基-1,4-苯醌（NSC 220334）和5-氯-6-ω-环己基己基巯基-2,3-二甲氧基-1,4-苯醌（NSC 238136）对K 562c细胞系也有活性，并且对大鼠的沃克癌肉瘤256显示出治愈效果。
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