Muni I A, Schneider F H, Olsson T A, King M
Natl Cancer Inst Monogr. 1984 Dec;66:85-90.
The tissue distribution and excretion of [3H]8-methoxypsoralen (8-MOP), a well-accepted therapeutic agent for the treatment of psoriasis, was studied in hairless HRA/Skh female mice. Mice were given single oral doses of 6 mg of [3H]8-MOP or 5-[14C]8-MOP/kg in corn oil. Radiochemical analyses of tissues and excreta were accomplished by liquid scintillation counting. The 8-MOP appeared to be rapidly absorbed through the gastrointestinal tract, where the tritium levels were highest, followed by skin, blood, and liver; levels were lowest in fat (adipose tissue). In female HRA/Skh mice which had not been irradiated with UVA (320-400 nm), 84% of the carbon-14 and 58% of the tritium were recovered in the urine and feces within 24 hours of oral administration of 5-[14C]8-MOP or [3H]8-MOP, respectively. Animals that were exposed to UVA and received [3H]8-MOP excreted approximately 12% less tritium in the urine and feces compared with the animals which received no UVA.
在无毛HRA/Skh雌性小鼠中研究了[3H]8-甲氧基补骨脂素（8-MOP）的组织分布和排泄情况，8-MOP是一种广泛认可的用于治疗银屑病的治疗剂。给小鼠经口单次给予6mg[3H]8-MOP或5-[14C]8-MOP/kg溶于玉米油中。通过液体闪烁计数对组织和排泄物进行放射化学分析。8-MOP似乎通过胃肠道迅速吸收，胃肠道中的氚水平最高，其次是皮肤、血液和肝脏；脂肪（脂肪组织）中的水平最低。在未接受UVA（320 - 400nm）照射的雌性HRA/Skh小鼠中，口服5-[14C]8-MOP或[3H]8-MOP后24小时内，分别有84%的碳-14和58%的氚在尿液和粪便中回收。与未接受UVA的动物相比，接受UVA并给予[3H]8-MOP的动物在尿液和粪便中排泄的氚减少了约12%。
