Wulf H C
Photodermatol. 1984 Dec;1(6):293-7.
Mice had 14C-8-MOP and 3H-8-MOP administered in therapeutic doses by gavage and the distribution of radioactivity in the animals was examined by autoradiography of wholebody sections. Animals were examined from 1 hour to 168 h after medication. The highest radioactivity was found 1 h after medication and the same distribution of radioactivity was found independent of time after medication. Very high radioactivity was found in the digestive system, the urine, the gall bladder, and the larger bileducts of the liver. 3H-8-MOP accumulated in the retina whereas 14C-8-MOP was not seen; this difference proves that the substance accumulated in the retina was a metabolite. Repeated medications 3 times weekly for 3 weeks led to accumulation. No additional accumulation was registered after UVA irradiation.
通过灌胃给小鼠施用治疗剂量的14C - 8 - 甲氧补骨脂素和3H - 8 - 甲氧补骨脂素，并通过全身切片的放射自显影检查动物体内放射性的分布。在给药后1小时至168小时对动物进行检查。给药后1小时发现放射性最高，且给药后不同时间的放射性分布相同。在消化系统、尿液、胆囊和肝脏的较大胆管中发现了非常高的放射性。3H - 8 - 甲氧补骨脂素在视网膜中积累，而未观察到14C - 8 - 甲氧补骨脂素；这种差异证明在视网膜中积累的物质是一种代谢产物。每周重复给药3次，持续3周会导致积累。紫外线A照射后未记录到额外的积累。
