Benignus V A
Neurobehav Toxicol Teratol. 1984 Nov-Dec;6(6):473-83.
The electroencephalogram (EEG) is a promising measure in the field of neurotoxicology. It can be well quantified by techniques which can be interpreted both physically and statistically although not necessarily physiologically. Such quantification schemes are briefly discussed in this paper. However, the quantification of EEG is not trivial in either the mathematical or computational sense. The relationship of EEG to brain function or brain pathology is not very well understood by some standards, perhaps due to poor quantitative methods or erroneous assumptions about brain-behavior relationships. EEG has a similar appearance across species. Hence the measure has great promise as a cross-species indicator of neurotoxicity. Not many quantitatively sound neurotoxicological studies using EEG have been published. It must be strongly emphasized that (a) more methods development is needed before the promise of cross species generality can be realized and (b) naive and/or half-hearted attempts to use this measure are perilous.
脑电图（EEG）是神经毒理学领域一种很有前景的测量方法。它可以通过物理和统计方法进行很好的量化，尽管不一定能从生理学角度进行解释。本文简要讨论了此类量化方案。然而，脑电图的量化在数学或计算意义上都并非易事。按照某些标准，脑电图与脑功能或脑病理学之间的关系尚未得到很好的理解，这可能是由于定量方法欠佳或对脑-行为关系的错误假设所致。脑电图在不同物种间具有相似的表现。因此，该测量方法作为神经毒性的跨物种指标具有很大潜力。目前已发表的使用脑电图的定量合理的神经毒理学研究并不多。必须着重强调的是：（a）在实现跨物种通用性的前景之前，需要更多方法的开发；（b）天真和/或敷衍地尝试使用该测量方法是危险的。
