Papanicolaou A C, Loring D W, Eisenberg H M
Neurobiol Aging. 1984 Winter;5(4):291-5. doi: 10.1016/0197-4580(84)90005-8.
Age-related differences in cerebral responsiveness to stimuli as reflected by the recovery cycle of cortical auditory evoked potentials (EPs) were investigated in healthy young and elderly adults. Pairs of identical tones separated by a fixed 350 msec interval were presented at rates of 1.0/sec, 0.5/sec, and 0.2/sec (inter-pair-intervals of 650, 1650, or 4650 msec). No age difference in the P1-N1 or N1-P2 amplitudes to either tone of the pair was present with the two faster stimulation rates. However, age-specific amplitude effects emerged for the slowest rate. The P1-N1 and especially the N1-P2 amplitude of the EP to the first as compared to that of the second tone was greatly enhanced among the young, but not as much among the elderly adults. Similarly, group differences in baseline to N1 and P2 amplitude measures of EPs to the first tone of the pair were most pronounced at the fastest stimulation rate. These data indicate clear differences in the recovery cycle of EPs between normal young and elderly subjects and demonstrate the applicability of the two-tone stimulation procedure in the assessment of cerebral responsivity in normal and pathologic populations.
通过皮层听觉诱发电位（EP）恢复周期反映的大脑对刺激反应的年龄相关差异，在健康的年轻人和老年人中进行了研究。以1.0/秒、0.5/秒和0.2/秒的速率（配对间隔为650、1650或4650毫秒）呈现间隔固定为350毫秒的相同音调对。在两种较快的刺激速率下，对该对音调中任一音调的P1-N1或N1-P2振幅不存在年龄差异。然而，在最慢的速率下出现了年龄特异性的振幅效应。与第二个音调相比，年轻人中EP对第一个音调的P1-N1尤其是N1-P2振幅大大增强，而在老年人中则没有那么明显。同样，在最快的刺激速率下，EP对该对音调中第一个音调的基线到N1和P2振幅测量的组间差异最为明显。这些数据表明正常年轻人和老年人之间EP恢复周期存在明显差异，并证明了双音刺激程序在评估正常和病理人群大脑反应性中的适用性。
