Hem A L, Sannes E, Nafstad I, Nicolaissen B
NIPH Ann. 1984 Dec;7(2):41-5.
Pregnant Belted Dutch rabbits were administered lynestrenol (17-alpha-ethynyl-oestr-4-en-17-beta-ol) orally on days 6-18 of gestation at a dose of 0.5 mg/kg/day. The dose littered on term and the surviving offspring were observed until four weeks old. Neurological disturbances characterized by behavioural abnormalities and locomotor disabilities were observed. About 40% of the offspring died within four weeks, and more than 70% of these had congenital malformations.
在妊娠第6至18天，给怀孕的带纹荷兰兔口服炔雌醇（17-α-乙炔基-4-雌烯-17-β-醇），剂量为0.5毫克/千克/天。记录足月产仔数，并观察存活后代至四周龄。观察到以行为异常和运动障碍为特征的神经功能紊乱。约40%的后代在四周内死亡，其中超过70%有先天性畸形。
