Varese L A, Grazioli F, Antoniola P, Viretto A, Vighetti A
Pediatr Med Chir. 1984 Jan-Feb;6(1):57-64.
Evidence that cure in acute, uncomplicated UTI will be achieved with a single-dose treatment is reported. In according with experimental works on pyelonephritis and pharmacological and pharmacocynetic data on new aminoglycoside antibiotics, authors proposed a new approach in the management of UTI, acute bacterial pyelonephritis and asymptomatic bacteriuria in children. Association of bolus dose therapy, non chemoantibiotical control of periurethral and intestinal ecosystem, with frequent and systematic monitoring of bacteriuria, seems to be effective to control infection and to prevent the development of renal scarring. Management of UTI in childhood could be easier and not require intensive and prolonged courses of antimicrobial therapy.
有报道称，单剂量治疗可治愈急性、非复杂性尿路感染。根据肾盂肾炎的实验研究以及新型氨基糖苷类抗生素的药理学和药代动力学数据，作者提出了一种治疗儿童尿路感染、急性细菌性肾盂肾炎和无症状菌尿症的新方法。大剂量冲击疗法、对尿道周围和肠道生态系统的非化学抗生素控制以及对菌尿症的频繁和系统监测相结合，似乎对控制感染和预防肾瘢痕形成有效。儿童尿路感染的治疗可能会更简便，且无需强化和长期的抗菌治疗疗程。
