Ingvar C, Erichsen C, Jönsson P E
Tumori. 1984 Dec 31;70(6):529-33. doi: 10.1177/030089168407000610.
Between 1976 and 1982, 110 isolated regional lymph node dissections (RLND) for melanoma were performed as a prophylactic procedure (PLND) in 44 and therapeutic procedure (TLND) in 64 patients. The prevalence of metastases was 20% in the PLND group. The number of patients with complications in the PLND were 17/44 (39%) and in the TLND 39/64 (61%). Local wound complications dominated. Serum collections occurred in 25% of PLND patients and 45% of TLND patients (p less than 0.05), and infections, skin necrosis, and cellulitis in respectively 11% and 22%. The incidence of lymphedema was 10% in PLND and 23% in TLND patients. Regarding the anatomic sites, there were significantly more seromas after axillary dissection in TLND patients compared with PLND patients (p less than 0.05). However, no difference was observed between groin dissections in the 2 groups. The socioeconomic effects in terms of hospital stay and further therapeutic measures were pronounced when complications occurred.
1976年至1982年间，对黑色素瘤患者进行了110例孤立区域淋巴结清扫术（RLND），其中44例为预防性手术（PLND），64例为治疗性手术（TLND）。PLND组转移率为20%。PLND组并发症患者有17/44（39%），TLND组有39/64（61%）。局部伤口并发症占主导。血清积液在PLND患者中发生率为25%，在TLND患者中为45%（p<0.05），感染、皮肤坏死和蜂窝织炎分别为11%和22%。淋巴水肿发生率在PLND患者中为10%，在TLND患者中为23%。就解剖部位而言，TLND患者腋窝清扫术后血清肿明显多于PLND患者（p<0.05）。然而，两组腹股沟清扫术之间未观察到差异。当出现并发症时，住院时间和进一步治疗措施方面的社会经济影响较为显著。
