Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA.
Arch Phys Med Rehabil. 2010 Jul;91(7):1070-6. doi: 10.1016/j.apmr.2010.03.021.
To assess the feasibility of recruiting and retaining cancer survivors with lower-limb lymphedema into an exercise intervention study. To develop preliminary estimates regarding the safety and efficacy of this intervention. We hypothesized that progressive weight training would not exacerbate leg swelling and that the intervention would improve functional mobility and quality of life.
Before-after pilot study with a duration of 5 months.
University of Pennsylvania.
Cancer survivors with a known diagnosis of lower-limb lymphedema (N=10) were directly referred by University of Pennsylvania clinicians. All 10 participants completed the study.
Twice weekly slowly progressive weight lifting, supervised for 2 months, unsupervised for 3 months.
The primary outcome was interlimb volume differences as measured by optoelectronic perometry. Additional outcome measures included safety (adverse events), muscle strength, objective physical function, and quality of life.
Interlimb volume differences were 44.4% and 45.3% at baseline and 5 months, respectively (pre-post comparison, P=.70). There were 2 unexpected incident cases of cellulitis within the first 2 months. Both resolved with oral antibiotics and complete decongestive therapy by 5 months. Bench and leg press strength increased by 47% and 27% over 5 months (P=.001 and P=.07, respectively). Distance walked in 6 minutes increased by 7% in 5 months (P=.01). No improvement was noted in self-reported quality of life.
Recruitment of patients with lower-limb-lymphedema into an exercise program is feasible. Despite some indications that the intervention may be safe (eg, a lack of clinically significant interlimb volume increases over 5 mo), the unexpected finding of 2 cellulitic infections among the 10 participants suggests additional study is required before concluding that patients with lower-extremity lymphedema can safely perform weight lifting.
评估招募和保留下肢淋巴水肿癌症幸存者参与运动干预研究的可行性。初步评估该干预措施的安全性和有效性。我们假设渐进式重量训练不会加重腿部肿胀，并且该干预措施将改善功能移动性和生活质量。
为期 5 个月的前后试点研究。
宾夕法尼亚大学。
直接由宾夕法尼亚大学临床医生推荐的患有已知下肢淋巴水肿（N=10）的癌症幸存者。所有 10 名参与者均完成了研究。
每周两次缓慢进行渐进式举重训练，前两个月由监督，后三个月无人监督。
主要结果是光电体积描记法测量的肢体间体积差异。其他观察指标包括安全性（不良事件）、肌肉力量、客观身体功能和生活质量。
肢体间体积差异分别为基线和 5 个月时的 44.4%和 45.3%（前后比较，P=.70）。在头 2 个月内，有 2 例意外发生蜂窝织炎的病例。通过 5 个月时的口服抗生素和完整的减压治疗均完全消退。5 个月内，bench 和腿部按压强度分别增加了 47%和 27%（P=.001 和 P=.07，分别）。5 个月内，6 分钟内步行距离增加了 7%（P=.01）。自我报告的生活质量没有改善。
招募下肢淋巴水肿患者参与运动计划是可行的。尽管有一些迹象表明该干预措施可能是安全的（例如，在 5 个月内肢体间体积没有明显增加），但在 10 名参与者中，有 2 例意外发生蜂窝织炎的发现表明，在得出患有下肢淋巴水肿的患者可以安全举重之前，还需要进一步研究。
