Riefkohl R, Cole N M, Cox E B
Aesthetic Plast Surg. 1984;8(4):227-30. doi: 10.1007/BF01570708.
In a prospective study of 211 outpatients undergoing cosmetic surgical procedures under local anesthesia supplemented with intravenous diazepam and morphine, patient pain response to the local anesthetic infiltration was graded and the recall of the operative experience was assessed. One hundred and fifty-five patients (73%) had either no pain response or a mild response, 41 (19%) had a moderate response, and 15 (7%) had a severe response. One hundred and eighty-seven patients (88%) had total amnesia for the local anesthetic infiltration and the operative procedure, and 183 (87%) could not recall pain, but had recall of events during surgery. There were no untoward drug reactions nor episodes of cardiorespiratory depression. We conclude that intravenous diazepam with or without intravenous morphine following triazolam, morphine, and premethazine premedication is a safe and effective regimen for outpatient surgery.
在一项针对211例接受局部麻醉并辅以静脉注射地西泮和吗啡的美容外科手术门诊患者的前瞻性研究中，对患者对局部麻醉药浸润的疼痛反应进行了分级，并评估了其对手术经历的回忆情况。155例患者（73%）无疼痛反应或仅有轻微反应，41例（19%）有中度反应，15例（7%）有重度反应。187例患者（88%）对局部麻醉药浸润和手术过程完全失忆，183例（87%）记不起疼痛，但能回忆起手术中的事件。未发生药物不良反应，也没有心肺抑制事件。我们得出结论，在三唑仑、吗啡和异丙嗪术前用药后，静脉注射地西泮加或不加静脉注射吗啡是门诊手术的一种安全有效的方案。
