[Effects of intravenous urography using sodium and meglumine ioxitalamate (Telebrix 38) on blood creatinine and urinary excretion of N-acetyl-beta-D-glucosaminidase].

We evaluated the effect of intravenous pyelography (IVP) with sodium ioxitalamate and meglumine (Telebrix 38) on serum creatinine levels and urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG). Both values were significantly elevated 24 and 48 hours following intravenous pyelography. The increase of urinary NAG however, was much greater than that of the serum creatinine level. In patients with normal serum creatinine levels prior to the IVP, urinary NAG was very elevated at 24 hours and had returned to almost normal values 48 hours after intravenous pyelography. On the contrary, urinary NAG was increased at 48 hours as well as at 24 hours in patients with chronic renal failure following administration of Telebrix 38. It was not possible to demonstrate any correlation between NAG urinary excretion and the amount of iodinated contrast material administered, even in patients with normal renal function.