Sokal J A, Majka J, Palus J
Arch Toxicol. 1984 Dec;56(2):106-8. doi: 10.1007/BF00349080.
Tissue carbon monoxide (CO) content was investigated in rats severely intoxicated with CO under various exposure conditions: 1% CO for 4 min, 0.4% CO for 40 min and 0.12% CO for 12 h. Extravascular CO was determined in the heart and skeletal muscles immediately after termination of exposure, and carboxymyoglobin (MbCO) percent saturation was calculated. Total brain CO was estimated immediately after termination of exposure and after the time periods of restitution. After the same exposure conditions, MbCO percent saturation was higher in the heart than in skeletal muscle. In both types of muscle, saturation of myoglobin (Mb) with CO depended on blood carboxyhemoglobin (HbCO) level and not on the duration of exposure. The time course of CO elimination was the same for blood and brain, irrespective of CO exposure conditions. The results obtained showed that acute CO intoxication induced by long duration exposures did not involve CO accumulation in the tissues.
研究了在不同暴露条件下严重一氧化碳（CO）中毒大鼠的组织一氧化碳（CO）含量：1% CO暴露4分钟、0.4% CO暴露40分钟和0.12% CO暴露12小时。暴露结束后立即测定心脏和骨骼肌中的血管外CO，并计算羧基肌红蛋白（MbCO）的饱和度百分比。暴露结束后以及恢复一段时间后立即估算全脑CO含量。在相同的暴露条件下，心脏中MbCO的饱和度百分比高于骨骼肌。在这两种类型的肌肉中，肌红蛋白（Mb）与CO的饱和度取决于血液中碳氧血红蛋白（HbCO）水平，而不取决于暴露持续时间。无论CO暴露条件如何，血液和大脑中CO消除的时间进程是相同的。所得结果表明，长时间暴露引起的急性CO中毒并不涉及组织中CO的蓄积。
