Sakamoto T, Sawada Y, Nishide K, Sadamitsu D, Yoshioka T, Sugimoto T, Nishii S, Kishi H
Arch Toxicol. 1984 Dec;56(2):136-8. doi: 10.1007/BF00349087.
A case of late-onset manifestation of organophosphorous insecticide poisoning is described. The patient was a 70-year-old female who ingested 40 ml Sumithion emulsion (50% fenitrothion). At first, no toxic symptoms were apparent. However, 48 h after ingestion certain signs became apparent. An impediment in consciousness was observed. Fasciculation and muscular weakness were noted, while plasma and urinary 4-nitro-3-methylphenol (NMC), the degradation product of Sumithion, reached a maximum. Neither atropine sulfate nor PAM (pyridine 2-aldoxime methiodine) were effective. For 3 weeks the patient required ventilatory support, and consequently her muscle strength and neurological status gradually recovered with falling NMC levels.
本文描述了一例有机磷杀虫剂中毒迟发表现的病例。患者为一名70岁女性，摄入了40毫升速灭松乳剂（50%杀螟硫磷）。起初，并无明显中毒症状。然而，摄入后48小时出现了某些体征。观察到意识障碍。出现了肌束震颤和肌肉无力，同时速灭松的降解产物血浆和尿液4-硝基-3-甲基苯酚（NMC）达到最高值。硫酸阿托品和氯解磷定均无效。患者需要通气支持3周，随后随着NMC水平下降，其肌肉力量和神经状态逐渐恢复。
