Arps H, Dietel M, Otto U
Folia Histochem Cytobiol. 1984;22(3-4):173-7.
29 non-endocrine tumors with clinical suspicion of paraneoplastic hypercalcemia were examined using immunohistochemistry specific for PTH and CT. In 19 of these cases intracellular immunoprecipitates have been demonstrable thus showing the paraneoplastic production of peptide hormones (18 PTH, 1 CT). Four of these tumors have been tested in tissue culture for in vitro production of endocrine active substances. In all cases the incubation medium yielded a positive reaction for PTH. The use of immunocytochemistry in the differential diagnosis of hypercalcemia in tumor patients is discussed.
对29例临床怀疑为副肿瘤性高钙血症的非内分泌肿瘤进行了甲状旁腺激素（PTH）和降钙素（CT）特异性免疫组化检查。其中19例可见细胞内免疫沉淀物，提示存在副肿瘤性肽类激素分泌（18例PTH，1例CT）。对其中4例肿瘤进行了组织培养，检测其体外内分泌活性物质的产生情况。所有病例的培养液对PTH均呈阳性反应。本文讨论了免疫细胞化学在肿瘤患者高钙血症鉴别诊断中的应用。
