Meyer J, Abt E
Growth. 1984 Winter;48(4):455-65.
Rats 16 weeks old were fed a liquified diet consisting of a suspension of finely ground commercial rat pellets for a period of 35 days. Weight-matched controls were fed isocaloric amounts of the dry pellets. Numbers of dividing epithelial cells and dimensions of the cellular and keratin layers were determined using precisely matched homologous areas in histologic sections from experimental animals and controls. Three mucosal regions which during the masticatory movements in controls are subjected to friction, compression and deformation ("masticatory mucosa") and one region subjected to distension and friction ("lining mucosa") showed experimental mitotic rates ranging from one-fourth to less than half the rates in controls. The epithelium of experimental masticatory mucosa showed consistent, statistically significant atrophic changes in both cellular and keratin layers, while that of lining mucosa showed atrophic changes in the cellular layer only. It is concluded that the concept of disuse atrophy should be extended to include oral surface epithelia.
给16周龄的大鼠喂食一种液化饮食，该饮食由精细研磨的商业大鼠颗粒饲料的悬浮液组成，持续35天。体重匹配的对照组喂食等热量的干颗粒饲料。使用来自实验动物和对照组的组织学切片中精确匹配的同源区域，确定分裂上皮细胞的数量以及细胞层和角质层的尺寸。在对照组咀嚼运动期间受到摩擦、压缩和变形的三个黏膜区域（“咀嚼黏膜”）和一个受到扩张和摩擦的区域（“衬里黏膜”），其实验有丝分裂率为对照组的四分之一至不到一半。实验性咀嚼黏膜的上皮细胞层和角质层均出现一致的、具有统计学意义的萎缩变化，而衬里黏膜仅在细胞层出现萎缩变化。得出的结论是，废用性萎缩的概念应扩展到包括口腔表面上皮。
