Roberts R S, Julian J A, Muir D C, Shannon H S
IARC Sci Publ. 1984(53):23-35.
An historical prospective mortality study of INCO's Ontario work-force has been conducted. A cohort of approximately 54 000 men, employed in all aspects of the extraction and refining of copper and nickel from the Sudbury ore deposit, have been followed for mortality between 1950 and 1976. A total of 5 283 deaths were identified by computerized record-linkage to the Canadian Mortality Data Base of death certificates. The analysis focuses on mortality from cancer of the nasal sinuses, larynx, lung, and kidney. Little evidence was found for increased mortality from laryngeal or kidney cancer, but lung and nasal cancer deaths were clearly elevated in men exposed to the two Sudbury area sinter plants and at Port Colborne in the leaching, calcining, and sintering department. The standardized mortality ratio (SMR) for lung cancer increases linearly with increasing duration of exposure and there is no evidence of a threshold. The nasal cancer mortality rate also rises linearly with duration of exposure. While lung cancer has a greater excess in the Sudbury sinter plant than at Port Colborne, the reverse is true for mortality from nasal cancer, which is ten times more frequent at Port Colborne than at Sudbury.
对国际镍公司安大略省员工进行了一项历史性前瞻性死亡率研究。对大约54000名从事从萨德伯里矿床开采和提炼铜及镍各个环节工作的男性进行了跟踪，记录他们在1950年至1976年期间的死亡率。通过计算机将记录与加拿大死亡证明数据库相链接，共识别出5283例死亡病例。分析重点关注鼻窦癌、喉癌、肺癌和肾癌的死亡率。未发现喉癌或肾癌死亡率增加的明显证据，但在接触萨德伯里地区两座烧结厂以及科尔伯恩港浸出、煅烧和烧结部门的男性中，肺癌和鼻癌死亡人数明显增加。肺癌的标准化死亡率（SMR）随接触时间的增加呈线性上升，且没有阈值证据。鼻癌死亡率也随接触时间呈线性上升。虽然萨德伯里烧结厂的肺癌超额死亡率高于科尔伯恩港，但鼻癌死亡率情况相反，科尔伯恩港的鼻癌死亡率是萨德伯里的十倍。
