正常受试者和慢性肾衰竭患者体内前体亚硝基化合物的分析及肠道代谢
Analysis for and intestinal metabolism of precursor nitroso compounds in normal subjects and in patients with chronic renal failure.
作者信息
Simenhoff M L, Dunn S R, Lele P S
出版信息
IARC Sci Publ. 1984(57):161-70.
PMID:6533003
Abstract
We have demonstrated that patients with chronic renal failure generate increased amounts of both dimethylamine and N-nitrosodimethylamine in the small bowel in association with aerobic and anaerobic bacterial overgrowth. The significance of these findings in relation to the reported increased incidence of cancer in patients with chronic renal failure has not yet been defined.
摘要
我们已经证明，慢性肾衰竭患者小肠中二甲胺和N-亚硝基二甲胺的生成量会增加，这与需氧菌和厌氧菌的过度生长有关。这些发现与报道的慢性肾衰竭患者癌症发病率增加之间的关系尚未明确。
相似文献
1
2
Evidence for generation of the precarcinogen nitrosodimethylamine in the small intestine in chronic renal failure.慢性肾衰竭患者小肠中致癌物亚硝基二甲胺生成的证据。
Kidney Int Suppl. 1983 Dec;16:S229-33.
3
Importance of aliphatic amines in uremia.脂肪族胺在尿毒症中的重要性。
Kidney Int Suppl. 1978 Jun(8):S16-9.
4
Nutritional and metabolic modulation of the carcinogen nitrosodimethylamine in chronic renal failure.慢性肾衰竭中致癌物二甲基亚硝胺的营养与代谢调节
Kidney Int Suppl. 1987 Oct;22:S159-61.
5
Quantitation of dimethylnitrosamine in the whole mouse after biosynthesis in vivo from trace levels of precursors.体内由痕量前体生物合成后全小鼠中二甲基亚硝胺的定量分析。
Science. 1977 Aug 26;197(4306):917-8. doi: 10.1126/science.887934.
6
Neutrophil-mediated formation of carcinogenic N-nitroso compounds in an in vitro model for intestinal inflammation.在肠道炎症体外模型中，中性粒细胞介导致癌性N-亚硝基化合物的形成。
Toxicol Lett. 2004 Dec 30;154(3):175-82. doi: 10.1016/j.toxlet.2004.07.013.
7
[Dimethylamine].[二甲胺]
Nihon Rinsho. 2004 Dec;62 Suppl 12:512-4.
8
9
10
N-nitroso compounds in gastric juice and their relationship to gastroduodenal disease.胃液中的N-亚硝基化合物及其与胃十二指肠疾病的关系。
IARC Sci Publ. 1982(41):345-55.
Zotero 插件