Mayrhofer F, Thumb N
Int J Clin Pharmacol Res. 1984;4(6):415-7.
In 15 patients with inflammatory and degenerative joint disease the concentrations of lonazolac were measured in serum and synovial fluid at steady state conditions. The mean concentration in the synovial fluid in 14 patients was 0.275 microgram/ml, which was 48% of that in the serum. For the patients with inflammatory joint disease, the synovial fluid concentration of lonazolac was 61% of that in the serum whereas in degenerative joint disease it reached only 39%.
在15例患有炎性和退行性关节疾病的患者中，在稳态条件下测量了血清和滑液中氯那唑酸的浓度。14例患者滑液中的平均浓度为0.275微克/毫升，为血清中浓度的48%。对于患有炎性关节疾病的患者，氯那唑酸的滑液浓度为血清浓度的61%，而在退行性关节疾病中仅为39%。
