Mir S, Shuman L S, Wright K C, Bechtel W, Kudo S
Invest Radiol. 1984 Mar-Apr;19(2):119-22. doi: 10.1097/00004424-198403000-00008.
Six adult mongrel dogs received bilateral sequential renal arterial injections of degradable starch microspheres following preadministration arteriograms. Renal arterial flow was measured using electromagnetic flow probes, and microspheres were administered until flow was blocked completely. One kidney in each dog was subjected to immediate postembolization arteriography, while the contralateral kidney served as a control. In the control kidneys, arterial flow returned to 90-95% of baseline within 30 minutes of embolization, and angiography at this time revealed a normal nephrogram. Blood flow in the kidneys that received postembolization arteriography returned to only 60-65% of baseline, even when followed up to 1 hour. Angiography at this time revealed persistent defects in the nephrogram. The effect of heparin, Renografin-60, and distilled deionized water on amylase activity was evaluated in vitro. No change in enzyme activity was noted.
六只成年杂种狗在进行动脉造影术前接受了双侧肾动脉顺序注射可降解淀粉微球。使用电磁血流探头测量肾动脉血流，并注射微球直至血流完全阻断。每只狗的一侧肾脏在栓塞后立即进行动脉造影，而对侧肾脏作为对照。在对照肾脏中，栓塞后30分钟内动脉血流恢复至基线的90 - 95%，此时血管造影显示肾图正常。接受栓塞后动脉造影的肾脏中的血流即使随访至1小时也仅恢复至基线的60 - 65%。此时血管造影显示肾图持续存在缺损。在体外评估了肝素、泛影葡胺-60和去离子蒸馏水对淀粉酶活性的影响。未观察到酶活性的变化。
