Brady T M, Singer D, Weiss C A, Smolin M F, Brinker R E, Cho K J
Invest Radiol. 1982 Sep-Oct;17(5):479-85. doi: 10.1097/00004424-198209000-00008.
Diatrizoate meglumine and sodium (Renografin-76) was perfused in an obstructed renal artery in 13 dogs. Intense and prolonged accumulation of contrast agent ("contrast staining") was achieved in all animals. Repeat injection was frequently necessary to enhance staining. Renin output from the stained kidneys was lower than that from the opposite kidneys. Angiography at 14-18 weeks demonstrated a marked decrease in renal size in all dogs, with complete occlusion of the renal artery in two dogs. No collateral circulation was discerned. Grossly, all experimental kidneys were uniformly shrunken. Histologically, diffuse renal infarction was evident with coagulative necrosis. Contrast staining is an effective method for uniform destruction of renal tissue.
将泛影葡胺和钠（泛影葡胺-76）注入13只犬的梗阻性肾动脉中。所有动物均实现了造影剂的强烈且持久的积聚（“造影剂染色”）。经常需要重复注射以增强染色效果。染色肾脏的肾素输出低于对侧肾脏。14至18周时的血管造影显示所有犬的肾脏大小均显著减小，两只犬的肾动脉完全闭塞。未发现侧支循环。大体上，所有实验肾脏均均匀萎缩。组织学上，可见弥漫性肾梗死伴凝固性坏死。造影剂染色是均匀破坏肾组织的有效方法。
