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血小板活化：豚鼠C3a过敏毒素的一种新生物活性。

Platelet activation: a new biological activity of guinea-pig C3a anaphylatoxin.

作者信息

Becker S, Meuer S, Hadding U, Bitter-Suermann D

出版信息

Scand J Immunol. 1978;7(2):173-80. doi: 10.1111/j.1365-3083.1978.tb00441.x.

DOI:10.1111/j.1365-3083.1978.tb00441.x
PMID:653315
Abstract

3H-serotonin-release from labelled gp-platelets is established as a sensitive method for testing a new biological activity of gp-C3a anaphylatoxin in an autologous situation. Time-, dose- and temperature-dependent release reactions as well as specific inhibition by carboxypeptidase B and anti-C3a antibodies show that C3a is a potent and specific inducer of platelet activation. Inactive C3a does not induce 3H-serotonin-release but specifically inhibits the action of C3a on platelets.

摘要

从标记的糖蛋白血小板中释放³H-血清素已被确立为一种在自体情况下检测过敏毒素C3a新生物活性的灵敏方法。时间、剂量和温度依赖性释放反应以及羧肽酶B和抗C3a抗体的特异性抑制表明，C3a是血小板活化的有效且特异性诱导剂。无活性的C3a不会诱导³H-血清素释放，但能特异性抑制C3a对血小板的作用。

相似文献

1
Platelet activation: a new biological activity of guinea-pig C3a anaphylatoxin.血小板活化：豚鼠C3a过敏毒素的一种新生物活性。
Scand J Immunol. 1978;7(2):173-80. doi: 10.1111/j.1365-3083.1978.tb00441.x.
2
Demonstration of high-affinity binding sites for C3a anaphylatoxin on guinea-pig platelets.豚鼠血小板上C3a过敏毒素高亲和力结合位点的证明。
Scand J Immunol. 1978;8(6):551-5. doi: 10.1111/j.1365-3083.1978.tb00555.x.
3
Comparative study on biological activities of various anaphylatoxins (C4a, C3a, C5a). Investigations on their ability to induce platelet secretion.各种过敏毒素（C4a、C3a、C5a）生物活性的比较研究。关于它们诱导血小板分泌能力的研究。
Inflammation. 1981 Dec;5(4):263-73. doi: 10.1007/BF00911092.
4
Demonstration of a specific C3a receptor on guinea pig platelets.豚鼠血小板上特异性C3a受体的证实。
J Immunol. 1988 May 15;140(10):3496-501.
5
Platelet-serotonin release by C3a and C5a: two independent pathways of activation.C3a和C5a诱导的血小板-血清素释放：两条独立的激活途径
J Immunol. 1981 Apr;126(4):1506-9.
6
C3a induced activation and stimulus specific reversible desensitization of guinea pig platelets.C3a诱导豚鼠血小板活化及刺激特异性可逆脱敏。
Agents Actions Suppl. 1982;11:147-57.
7
Synthetic C3a analogs as specific inhibitors of C3a activity.
Immunopharmacology. 1981 Sep;3(3):275-80. doi: 10.1016/0162-3109(81)90009-6.
8
Pulmonary injury induced by C3a and C5a anaphylatoxins.C3a和C5a过敏毒素诱导的肺损伤。
Am J Pathol. 1980 Aug;100(2):327-48.
9
Immunopharmacology of anaphylatoxin-induced bronchoconstrictor responses.过敏毒素诱导的支气管收缩反应的免疫药理学
Complement. 1986;3(3):137-51. doi: 10.1159/000467891.
10
Effect of C3a and C5a anaphylatoxins on guinea-pig isolated blood vessels.C3a和C5a过敏毒素对豚鼠离体血管的作用。
J Pharmacol Exp Ther. 1984 Sep;230(3):749-54.

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J Transl Med. 2015 Aug 20;13:272. doi: 10.1186/s12967-015-0565-2.
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Low zone desensitization: a stimulus-specific control mechanism of cell response. Investigations on anaphylatoxin-induced platelet secretion.低区脱敏：细胞反应的一种刺激特异性控制机制。关于过敏毒素诱导血小板分泌的研究。
J Exp Med. 1982 Mar 1;155(3):698-710. doi: 10.1084/jem.155.3.698.
3
Comparative study on biological activities of various anaphylatoxins (C4a, C3a, C5a). Investigations on their ability to induce platelet secretion.
各种过敏毒素（C4a、C3a、C5a）生物活性的比较研究。关于它们诱导血小板分泌能力的研究。
Inflammation. 1981 Dec;5(4):263-73. doi: 10.1007/BF00911092.
4
Human platelet activation by C3a and C3a des-arg.C3a和C3a去精氨酸对人血小板的激活作用
J Exp Med. 1983 Aug 1;158(2):603-15. doi: 10.1084/jem.158.2.603.
5
Relationships among the complement, kinin, coagulation, and fibrinolytic systems.补体、激肽、凝血和纤溶系统之间的关系。
Springer Semin Immunopathol. 1983;6(2-3):231-58. doi: 10.1007/BF00205875.
6
Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements.通过肽类和非肽类元素组合设计新一代合成C3a类似物及其生物活性
Biochem J. 1988 Oct 1;255(1):209-16.
7
Evidence for in vivo degradation of C3a anaphylatoxin by mast cell chymase. I. Nonspecific activation of rat peritoneal mast cells by C3ades Arg.肥大细胞糜蛋白酶对C3a过敏毒素进行体内降解的证据。I. C3ades Arg对大鼠腹膜肥大细胞的非特异性激活
Am J Pathol. 1991 Jun;138(6):1359-69.
8
Functional activities of synthetic anaphylatoxic peptides in widely used biological assays.合成过敏毒素肽在广泛使用的生物学检测中的功能活性。
Clin Exp Immunol. 1992 May;88(2):368-72. doi: 10.1111/j.1365-2249.1992.tb03090.x.