Becker S, Hadding U, Schorlemmer H U, Bitter-Suermann D
Scand J Immunol. 1978;8(6):551-5. doi: 10.1111/j.1365-3083.1978.tb00555.x.
3H-serotonin release from guinea-pig platelets was demonstrated to be the consequence of C3a binding to these cells. A Scatchard analysis of dose-response data of the 125I-C3a binding pattern to guinea-pig platelets pointed to the existence of binding sites with high and low affinity for the C3a molecule (HA and LA receptors). HA receptors are specific for C3a with intact C-terminal arginine. whereas C3adesarg only interacts with LA receptors. The release of serotonin may be induced by a combined reaction of C3a with HA receptors and LA receptors on the platelet membrane.
已证明豚鼠血小板释放3H-血清素是C3a与这些细胞结合的结果。对125I-C3a与豚鼠血小板结合模式的剂量反应数据进行Scatchard分析表明，存在对C3a分子具有高亲和力和低亲和力的结合位点（HA和LA受体）。HA受体对具有完整C末端精氨酸的C3a具有特异性，而C3adesarg仅与LA受体相互作用。血清素的释放可能是由C3a与血小板膜上的HA受体和LA受体联合反应诱导的。
