Chen W Y, Horton D J
Scand J Respir Dis. 1978 Feb;59(1):13-20.
Pulmonary and thermoregulatory reactions to body cooling were studied in eight asthmatic and five normal subjects. The cooling was achieved by a cold shower at water temperature (T) of 15 degrees C for 1 min, followed by exposing the wet body to a high wind generated by a fan for another minute. The skin T, oral T and pulmonary functions were measured before and after cooling. After the cooling, skin T fell a mean of 7 degrees in all subjects and the oral T fell 0.5 degrees in the normals and 0.7 degrees in the asthmatics. In asthmatics, the post-cooling forced expiratory volume in 1 s (FEV1) and maximal mid-expiratory flow (MMEF) fell significantly (P less than .05) to a mean of 79% and 72%of baseline, respectively, and thoracic gas volume (TGV) and airway resistance (Raw) increased significantly to 133% and 198% of baseline, respectively. In normal subjects a small but significant increase in Raw was found. No obstruction developed in the asthmatics after a warm shower at 37 degrees or after breathing the cold shower mist. It is suggested that it is body cooling which leads first to vasoconstriction and then cooling of respiratory mucosa that initiates bronchoconstriction in asthmatics.
对8名哮喘患者和5名正常受试者进行了身体冷却时的肺部和体温调节反应研究。通过在水温（T）为15摄氏度的冷水中淋浴1分钟来实现冷却，然后将湿身暴露在风扇产生的强风中再持续1分钟。在冷却前后测量皮肤温度（T）、口腔温度和肺功能。冷却后，所有受试者的皮肤温度平均下降7摄氏度，正常受试者的口腔温度下降0.5摄氏度，哮喘患者下降0.7摄氏度。在哮喘患者中，冷却后第1秒用力呼气量（FEV1）和最大呼气中期流量（MMEF）显著下降（P<0.05），分别降至基线值的79%和72%，胸廓气体容积（TGV）和气道阻力（Raw）显著增加，分别升至基线值的133%和198%。在正常受试者中，发现Raw有小幅但显著的增加。在37摄氏度的温水淋浴后或吸入冷淋浴雾气后，哮喘患者未出现阻塞情况。研究表明，是身体冷却首先导致血管收缩，进而使呼吸道黏膜冷却，从而引发哮喘患者的支气管收缩。
