Ishizawa M
Nihon Heikatsukin Gakkai Zasshi. 1984 Oct;20(5):401-6. doi: 10.1540/jsmr1965.20.401.
Propulsive activity in segments of isolated distal colon of guinea-pig was investigated. Propulsive activity, as indicated by movements of the bolus (5 x 10 mm diameter) made of plastic with a steel wire, was recorded isometrically using a force-displacement transducer. Muscle tension of longitudinal axis was also recorded isometrically in the same preparation. In all preparations, spontaneous propulsive activity, which was due to combination of ascending excitation and descending inhibition, occurred periodically. The frequency of propulsive activity was 4.0 +/- 0.9/10 min (M +/- SE, n = 8) and the duration was 64.0 +/- 9.0 sec (M +/- SE, n = 9). The propulsive force was 16.4 +/- 3.4 g (M +/- SE, n = 10) at peak. The spontaneous propulsive activities were blocked by atropine (10(-5) g/ml). These activities were gradually decreased in frequency and in propulsive force within 2-3 hours. When spontaneous propulsive activities were negligible, carbachol (10(-9)-10(-7) g/ml) added to the bathing medium stimulated propulsive activity in a dose dependent manner.
对豚鼠离体远端结肠段的推进活动进行了研究。推进活动通过由钢丝制成的塑料丸（直径5×10毫米）的运动来表示，使用力-位移传感器等长记录。在同一标本中，也等长记录纵轴的肌肉张力。在所有标本中，由于上行兴奋和下行抑制的结合而产生的自发推进活动周期性出现。推进活动的频率为4.0±0.9/10分钟（平均值±标准误，n = 8），持续时间为64.0±9.0秒（平均值±标准误，n = 9）。峰值时的推进力为16.4±3.4克（平均值±标准误，n = 10）。自发推进活动被阿托品（10⁻⁵克/毫升）阻断。这些活动在2 - 3小时内频率和推进力逐渐降低。当自发推进活动可忽略不计时，添加到浴液中的卡巴胆碱（10⁻⁹ - 10⁻⁷克/毫升）以剂量依赖方式刺激推进活动。
