前列腺素F2α对豚鼠离体节段性结肠推进活动的影响。
Effect of prostaglandin F2 alpha on propulsive activity of the isolated segmental colon of the guinea-pig.
作者信息
Ishizawa M, Miyazaki E
出版信息
Prostaglandins. 1975 Nov;10(5):759-68. doi: 10.1016/0090-6980(75)90004-0.
The effects of prostaglandin F2alpha (PGF 2alpha) on propulsive activity in segments of isolated colon and on isolated strips of guinea-pig colon were investigated. Using experimental conditions under which spontaneous propulsive activity was negligible, PGF2alpha (5X10(-8)X1X10(-6)M), added to the bathing medium increased propulsive activity in a concentration dependent manner. This increase of propulsive activity was abolished in the presence of atropine or tetrodotoxin (1X10(-7)g/ml). The contractions produced by PGF2alpha (5X10(-7) -1X10(-5)M) in isolated longitudinal and circular smooth muscle strips of guinea-pig colon were unaffected in the presence of atropine or tetrodotoxin (1X10(-7) g/ml). From these results it is concluded that under the conditions employed in this study propulsive activity stimulated by PGF2alpha may depend on the contractions of both muscle layers and stimulation of the peristalic reflex.
研究了前列腺素F2α（PGF 2α）对离体结肠段推进性活动以及对豚鼠结肠离体条带的影响。在自发推进性活动可忽略不计的实验条件下，添加到浴液中的PGF2α（5×10⁻⁸～1×10⁻⁶M）以浓度依赖方式增加推进性活动。在阿托品或河豚毒素（1×10⁻⁷g/ml）存在时，这种推进性活动的增加被消除。在阿托品或河豚毒素（1×10⁻⁷g/ml）存在时，PGF2α（5×10⁻⁷～1×10⁻⁵M）在豚鼠结肠离体纵行和环行平滑肌条带中产生的收缩不受影响。从这些结果得出结论，在本研究采用的条件下，PGF2α刺激的推进性活动可能取决于两层肌肉的收缩以及蠕动反射的刺激。
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