Kellerman T S, Newsholme S J, Coetzer J A, Van der Westhuizen G C
Onderstepoort J Vet Res. 1984 Dec;51(4):271-4.
An outbreak of disease affecting a herd of 16 dairy cattle which were fed mouldy, sprouted maize is described. Eight of the cattle were affected, 5 of which died. The clinical signs included muscular tremors, hypersensitivity, ataxia, anorexia and salivation. Aspergillus clavatus was the only fungus isolated from the sprouts. Clinical signs that were indistinguishable from those in the field outbreak were reproduced by dosing the mouldy maize sprouts to a steer and a sheep, and by dosing another sheep with maize inoculated with a pure culture of A. clavatus isolated from the mouldy maize on the farm. Light microscopical examination revealed neuronal degeneration and necrosis in the midbrain, medulla oblongata and spinal cord of all 3 of these animals. The disease is clinically and pathologically indistinguishable from the disease caused by the ingestion of sorghum beer residue, and in certain respects it is similar to toxicoses caused by the ingestion of wheat sprouts and malt sprouts infested with A. clavatus.
本文描述了一起疾病暴发事件，涉及一群16头奶牛，这些奶牛食用了发霉发芽的玉米。其中8头牛受到影响，5头死亡。临床症状包括肌肉震颤、过敏、共济失调、厌食和流涎。棒曲霉是从芽苗中分离出的唯一真菌。通过给一头公牛和一只绵羊投喂发霉的玉米芽苗，以及给另一只绵羊投喂接种了从农场发霉玉米中分离出的棒曲霉纯培养物的玉米，再现了与现场暴发中难以区分的临床症状。光学显微镜检查发现，这3只动物的中脑、延髓和脊髓均出现神经元变性和坏死。该疾病在临床和病理上与因摄入高粱啤酒残渣引起的疾病无法区分，在某些方面与因摄入被棒曲霉污染的小麦芽苗和麦芽芽苗引起的中毒相似。
