[Tremorogenic mycotoxicosis caused by the fungi Aspergillus clavatus, clinical features, pathomorphology, and isolation of metabolites].

Tremorgenic mycotoxicosis of the fungus Aspergillus clavatus growing on malt sprouts under natural and laboratory conditions has been studied. The clinical aspect and pathomorphology of the diseases were investigated and a pure culture A. clavatus was isolated. Three schemes of cultivation of A. clavatus in laboratory conditions were tested to obtain tremorgens. The scheme of cultivation in thermostat at 37 degrees for 7 days and then at 30 degrees C for 10 days and at 22 degrees for 17 days afterwards was found to be optimal. A metabolite close to alkaloids by its physico-chemical characteristics was isolated from the fungus studied.