Tremasov M Ia, Smetov P K, Nazypov M N, Sergeĭchev A I
Prikl Biokhim Mikrobiol. 1993 Jan-Feb;29(1):56-9.
Tremorgenic mycotoxicosis of the fungus Aspergillus clavatus growing on malt sprouts under natural and laboratory conditions has been studied. The clinical aspect and pathomorphology of the diseases were investigated and a pure culture A. clavatus was isolated. Three schemes of cultivation of A. clavatus in laboratory conditions were tested to obtain tremorgens. The scheme of cultivation in thermostat at 37 degrees for 7 days and then at 30 degrees C for 10 days and at 22 degrees for 17 days afterwards was found to be optimal. A metabolite close to alkaloids by its physico-chemical characteristics was isolated from the fungus studied.
对在自然和实验室条件下麦芽上生长的棒曲霉导致的震颤性霉菌毒素中毒进行了研究。调查了该病的临床症状和病理形态，并分离出了棒曲霉的纯培养物。测试了在实验室条件下培养棒曲霉以获得震颤毒素的三种方案。结果发现，最佳方案是先在37摄氏度的恒温箱中培养7天，然后在30摄氏度下培养10天，之后在22摄氏度下培养17天。从所研究的真菌中分离出了一种理化特性与生物碱相近的代谢物。
