Schreiber R A, Ungar A L
Subst Alcohol Actions Misuse. 1984;5(5):255-62.
The time courses of changes in levels of beta-hydroxybutyrate (BOHB), glucose (GLC), and glycogen (GLY) were measured hourly for 7 h after i.p. 2 g/kg ethanol (ETOH) in samples of liver, blood, and brain in 21 day old C57BL/6J mice. After acute ETOH, brain GLC remained at 2.1 mmol/kg for 2 h, fell to a low of 1.5 mmol/kg at 5 h, then rose slightly. Blood GLC remained near 8 mmol/kg until 3 h, then fell. Liver GLC fell steadily from 10.2 to 7.2 mmol/kg at 7 h. Brain GLY rose from 1.7 to 2.9 mmol/kg at 3 h, then fell steadily. Blood GLY increased from 2.7 to 4.6 mmol/kg at 2 h, then fell to 1.7 mmol/kg. Liver GLY decreased from 70 to 30 mmol/kg. BOHB changes were similar in all samples. BOHB in brain fell from 0.12 to 0.08 mmol/kg at 2 to 3 h; then rose steadily to 0.27 mmol/kg at 7 h. Blood and liver BOHB fell from 0.40 to 0.25 mmol/kg, then rose to 1.0 mmol/kg. In a previous study, susceptibility to audiogenic seizures after 2 g/kg ETOH was completely suppressed for up to 1 h, then susceptibility increased to a maximum at 5 1/2 h, when a period of potentiation was observed. In this study, brain GLY levels were increased during the period of protection, and brain GLC levels were decreased during the period of potentiation. Together, these data may lend support to an hypothesis of an indirect effect of ETOH on the brain, leading to changes in susceptibility to audiogenic seizures via changes in metabolite availability.
给21日龄的C57BL/6J小鼠腹腔注射2 g/kg乙醇（ETOH）后，每小时测量一次肝脏、血液和大脑样本中β-羟基丁酸（BOHB）、葡萄糖（GLC）和糖原（GLY）水平变化的时间进程，持续7小时。急性乙醇处理后，大脑GLC在2小时内维持在2.1 mmol/kg，5小时降至最低点1.5 mmol/kg，然后略有上升。血液GLC在3小时前维持在8 mmol/kg左右，然后下降。肝脏GLC在7小时内从10.2 mmol/kg稳步下降至7.2 mmol/kg。大脑GLY在3小时时从1.7 mmol/kg升至2.9 mmol/kg，然后稳步下降。血液GLY在2小时时从2.7 mmol/kg增加至4.6 mmol/kg，然后降至1.7 mmol/kg。肝脏GLY从70 mmol/kg降至30 mmol/kg。所有样本中的BOHB变化相似。大脑中的BOHB在2至3小时内从0.12 mmol/kg降至0.08 mmol/kg；然后在7小时时稳步升至0.27 mmol/kg。血液和肝脏中的BOHB从0.40 mmol/kg降至0.25 mmol/kg，然后升至1.0 mmol/kg。在先前的一项研究中，2 g/kg乙醇处理后对听源性癫痫发作的易感性在长达1小时内完全受到抑制，然后易感性在5.5小时时增加到最大值，此时观察到一段增强期。在本研究中，大脑GLY水平在保护期内升高，大脑GLC水平在增强期内降低。总之，这些数据可能支持乙醇对大脑产生间接影响的假说，即通过代谢物可用性的变化导致听源性癫痫发作易感性的改变。
