Ethanol induces a transient susceptibility to audiogenic seizures in weanling C57BL/6J mice.

An acute dose of 5 g/kg ethanol led to a transient few days of a low incidence of susceptibility to audiogenic seizures in C57BL/6J mice (normally not susceptible) if the ethanol was administered during the transition from suckling to dietary self-sufficiency. This demonstrates a critical period of responsiveness to ethanol, shows ethanol-induced audiogenic priming, and may provide evidence for an indirect effect of ethanol on the brain.