Al-Awamy B H, Al-Muzan M, Al-Turki M, Serjeant G R
Trans R Soc Trop Med Hyg. 1984;78(6):792-4. doi: 10.1016/0035-9203(84)90023-3.
Neonatal screening for sickle cell disease has been established in three hospitals in the Eastern Province of Saudi Arabia. In the first 17 months of this programme, 5630 cord blood samples were screened with the detection of 47 babies with an FS phenotype. The sickle cell trait occurred in 4.4% births in Al Khobar, in 6.7% in Dammam and in 17.9% in Qatif. An apparent excess of the FS phenotype over that predicted from the observed S gene frequency occurred at all three centres. The cause of this excess remains unknown although a high prevalence of sickle cell-beta o thalassaemia and the effects of non-random mating may be contributory factors.
沙特阿拉伯东部省份的三家医院已开展新生儿镰状细胞病筛查。在该项目开展的前17个月，共筛查了5630份脐带血样本，检测出47例具有FS表型的婴儿。镰状细胞性状在胡拜尔的新生儿中发生率为4.4%，在达曼为6.7%，在盖提夫为17.9%。在所有三个中心，FS表型的实际发生率均明显高于根据观察到的S基因频率预测的发生率。尽管镰状细胞-βo地中海贫血的高患病率和非随机交配的影响可能是促成因素，但这种过高发生率的原因仍不明。
