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吡喹酮治疗前后人体肺吸虫病患者的血清抗体水平

Serum antibody levels in human paragonimiasis before and after therapy with praziquantel.

作者信息

Knobloch J, Paz G, Feldmeier H, Wegner D, Voelker J

出版信息

Trans R Soc Trop Med Hyg. 1984;78(6):835-6. doi: 10.1016/0035-9203(84)90038-5.

DOI:10.1016/0035-9203(84)90038-5
PMID:6533858
Abstract

Enzyme immunoassays (ELISA) and indirect haemagglutination (IHA) were used to determine IgG and IgE serum antibody levels in 43 patients from Ecuador before and after therapy with praziquantel. ELISA indicated infection more sensitively than IHA. The tendency of increasing antibody levels between the first and second month after therapy was more distinct when measured by IHA, whereas the decreases of antibody levels between the third and sixth month after treatment was more distinct when measured by ELISA. The IgG ELISA for detecting long persisting antibody was more sensitive than IHA.

摘要

采用酶免疫测定法(ELISA)和间接血凝试验(IHA)测定了43例来自厄瓜多尔的患者在接受吡喹酮治疗前后的血清IgG和IgE抗体水平。ELISA检测感染比IHA更敏感。治疗后第一个月和第二个月之间抗体水平上升的趋势用IHA测量时更明显,而治疗后第三个月和第六个月之间抗体水平下降的趋势用ELISA测量时更明显。用于检测长期存在抗体的IgG ELISA比IHA更敏感。

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Paragonimiasis.并殖吸虫病。
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Current status of Paragonimus and paragonimiasis in Ecuador.厄瓜多尔并殖吸虫及并殖吸虫病的现状
Mem Inst Oswaldo Cruz. 2014 Nov;109(7):849-55. doi: 10.1590/0074-0276140042. Epub 2014 Oct 14.
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Persisting antibody reaction in paragonimiasis after praziquantel treatment is elicited mainly by egg antigens.吡喹酮治疗后肺吸虫病中持续存在的抗体反应主要由虫卵抗原引起。
Korean J Parasitol. 2000 Jun;38(2):75-84. doi: 10.3347/kjp.2000.38.2.75.