Bellissimo J A, Cooper S L
Trans Am Soc Artif Intern Organs. 1984;30:359-63.
In this study protein adsorption was monitored under well-defined and nearly uniform flow conditions at the test surface. The adsorption profiles observed demonstrated that both tightly and loosely bound proteins may be present on the surface. An understanding of these differently adsorbed species is useful since it appears that they mediate the blood response to artificial materials. The change of characteristic peak positions observed for fibrinogen on germanium and Biomer surfaces may be significant if these spectral differences can be related to changes in protein structure and the in vivo performance of different biomaterials. Finally, the ability to study competitive adsorption is important since advances in this area may eventually led to an understanding of the role adsorbed proteins play in whole blood contact with artificial surfaces.
在本研究中，在测试表面明确且近乎均匀的流动条件下监测蛋白质吸附情况。观察到的吸附曲线表明，表面可能同时存在紧密结合和松散结合的蛋白质。了解这些不同吸附的物种很有用，因为它们似乎介导了血液对人工材料的反应。如果这些光谱差异能够与蛋白质结构的变化以及不同生物材料的体内性能相关联，那么在锗和Biomer表面观察到的纤维蛋白原特征峰位置的变化可能具有重要意义。最后，研究竞争性吸附的能力很重要，因为该领域的进展最终可能会让人了解吸附蛋白在全血与人工表面接触中所起的作用。
