Wendling P, Manz R, Thews G, Vaupel P
Adv Exp Med Biol. 1984;180:293-300. doi: 10.1007/978-1-4684-4895-5_28.
Tissue oxygenation was measured in 10 patients with differentiated adenocarcinoma in a very localized region in the middle part of the rectum (grade I - II, clinical stage II) by means of a cryophotometric micromethod. The results obtained clearly show that the oxygenation of differentiated rectal adenocarcinoma is distinctly lower than that of the normal rectal mucosa; tissue hypoxia or even anoxia are a common feature in those tumors; There exist considerable inter- individual differences among tumors of the same clinical staging and histological grading; substantial intra- individual heterogeneities in the oxygenation are evident within the same tumor and even within neighbouring microareas of the tissue. These findings imply that the commonly used classifications do not allow any conclusions concerning the oxygenation status, and probably the radiosensitivity of a tumor, respectively.
采用低温光度微法对10例直肠中段非常局限区域的分化型腺癌患者（I-II级，临床分期II期）进行组织氧合测定。所得结果清楚地表明，分化型直肠腺癌的氧合明显低于正常直肠黏膜；组织缺氧甚至无氧是这些肿瘤的常见特征；同一临床分期和组织学分级的肿瘤之间存在相当大的个体差异；在同一肿瘤内甚至在组织的相邻微区域内，氧合存在明显的个体内异质性。这些发现意味着常用的分类方法无法分别就肿瘤的氧合状态以及可能的放射敏感性得出任何结论。
