Corridori S, Gorini P, Trespi G, Baldini E
Boll Ist Sieroter Milan. 1984;63(6):529-33.
The authors have evaluated the effects of specific Immunoglobulins administration in order to prevent type B viral hepatitis. 34 members of care units entered a program of epidemiological surveillance after an occasional contamination with biological samples obtained from patients affected by type B viral hepatitis. All these subjects have been treated with two injections of specific immunoglobulins at the dose of 0.06 ml/kg. i.m.; the first was administered immediately after contamination and the second after one month. Serum antibody titres were determined by RIA techniques in a six months follow-up. The results seem to indicate that the degree of protectivity after passive immunization is poor and rather incostant.
作者评估了特异性免疫球蛋白给药对预防B型病毒性肝炎的效果。34名护理单位成员在偶然受到来自B型病毒性肝炎患者的生物样本污染后，进入了一项流行病学监测计划。所有这些受试者均接受了两次肌肉注射特异性免疫球蛋白治疗，剂量为0.06 ml/kg；第一次在污染后立即注射，第二次在一个月后注射。在六个月的随访中，通过放射免疫分析技术测定血清抗体滴度。结果似乎表明，被动免疫后的保护程度较差且相当不稳定。
