Scheiermann N, Kuwert E K
Dtsch Med Wochenschr. 1982 Dec 17;107(50):1918-22. doi: 10.1055/s-2008-1070233.
After intramuscular administration of four different hepatitis B immunoglobulins at a dose of 0.1 ml/kg body weight, serum anti-HBs antibody titres were followed over four months in 37 healthy persons. Highest serum concentration averaged 138-355 mU anti-HBs/ml and was generally observed on the third or seventh day after passive immunisation. Immunoglobulins were eliminated with a half-life of 17.5-25 days. Four months after injections their concentration was still 1.2-2.5% of the maximally reached serum level. Intramuscular administration of hepatitis B immunoglobulin does not at once achieve effective optimal viral antibody levels in blood. But since there are no special preparations for intravenous use and active immunization is unlikely to be able to provide immediate protection against hepatitis B virus, intramuscular injection remains further on the method of choice in the prevention of hepatitis B after exposure.
对37名健康人按0.1ml/kg体重的剂量肌肉注射四种不同的乙肝免疫球蛋白后，对其血清抗-HBs抗体滴度进行了四个月的跟踪监测。血清最高浓度平均为138-355mU抗-HBs/ml，通常在被动免疫后的第三天或第七天观察到。免疫球蛋白的消除半衰期为17.5-25天。注射四个月后，其浓度仍为血清最高水平的1.2-2.5%。肌肉注射乙肝免疫球蛋白不能立即在血液中达到有效的最佳病毒抗体水平。但由于没有特殊的静脉用制剂，且主动免疫不太可能立即提供针对乙肝病毒的保护，肌肉注射仍是暴露后预防乙肝的首选方法。
