Kanta J, Kopácová L, Patocková M, Bartos F
Pol J Pharmacol Pharm. 1984 Nov-Dec;36(6):659-63.
The effect of local anesthetics pentacaine ((+/-)-trans N-/2-(3-pentyloxy-phenylcarbamoyloxy)-cyclohexyl/- pyrrolidinium chloride), heptacaine (N-/2-(2-heptyloxy-phenyl-carbamoyloxy)-ethyl/-piperidini um chloride) and trimecaine (2, 4, 6-trimethylphenylcarbamoyl)-methyldiethylammonium chloride) on granulation tissue formation in open skin wounds was examined in rats. The anesthetics applied on the wounds 3 times a day for 5 days caused increase in granulation tissue weight, in DNA and hydroxyproline contents. Pentacaine had the most pronounced effects (190% dry weight, 253% DNA and 148% hydroxyproline content when compared to saline-treated controls). The smallest changes were observed after heptacaine treatment.
研究了局部麻醉药喷他卡因（(+/-)-反式N-/2-(3-戊氧基-苯基氨基甲酰氧基)-环己基/-吡咯烷氯化铵）、庚卡因（N-/2-(2-庚氧基-苯基氨基甲酰氧基)-乙基/-哌啶氯化铵）和三甲卡因（(2,4,6-三甲基苯基氨基甲酰基)-甲基二乙铵氯化物）对大鼠开放性皮肤伤口肉芽组织形成的影响。这些麻醉药每天在伤口上涂抹3次，持续5天，导致肉芽组织重量、DNA和羟脯氨酸含量增加。喷他卡因的作用最为显著（与生理盐水处理的对照组相比，干重增加190%，DNA增加253%，羟脯氨酸含量增加148%）。庚卡因处理后观察到的变化最小。
