Dráberová L, Nouza K
Folia Biol (Praha). 1981;27(2):107-14.
Two local anaesthetics, pentacaine and trimecaine, were assayed for their effects on immune reactivity of mice in the regional popliteal lymph node after local injection of the antigen, on the regional graft-versus-host reaction and on the ability to reject skin allografts. These local anaesthetics exhibited a dose-dependent, immunosuppressive effect on all the systems used, although the mechanism of their action was different: pentacaine exerted a destructive effect on lymphocytes, whereas trimecaine induced a blockade of the lymphocyte functions.
对两种局部麻醉药喷他卡因和三甲卡因进行了检测，观察它们在局部注射抗原后对小鼠腘窝局部淋巴结免疫反应性、局部移植物抗宿主反应以及排斥同种异体皮肤能力的影响。这些局部麻醉药对所有所使用的系统均表现出剂量依赖性的免疫抑制作用，尽管它们的作用机制有所不同：喷他卡因对淋巴细胞具有破坏作用，而三甲卡因则诱导淋巴细胞功能的阻断。
